Benzylamine → HCID 13007231, compound

Participants

Reaction Steps

A mixture of 1-(3,5-dibromo-4-nitropyrazol-1-yl)-propane-1,2-diol (3-4) (31 g, 898 mmol), EtOH (420 ml) and benzylamine (138 g, 1.26 mol) was refluxed for 1.5 hours. The reaction medium was concentrated to the maximum under reduced pressure. 100 ml of DCM were added to the residue. The organic phase was washed with dilute acid (5×50 ml). The organic phase was dried over Na2SO4 and the solvent was evaporated off under reduced pressure. The brown oil obtained was treated with diisopropyl ether at 0° C. to give the 3-(5-benzylamino-3-bromo-4-nitropyrazol-1-yl)propane-1,2-diol (14.1 g, 42%) in the form of a yellow solid.

Provenance & Evidence