反应详情

4-Methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine was first reacted with phenyl chloroformate as described for (4-methoxy-7-phenyl-benzothiazol-2-yl)-carbamic acid benzyl ester in WO01/97786 and then with methyl-(4-trifluoromethyl-cyclohexyl)-amine. Usual workup, flash-chromatography (silica, eluent dichloromethane/methanol) and final evaporation of the solvent afforded the title compound as white crystals (96% yield), mp 157-167° C. MS: m/e=473(M+H+). Following the general method of example 1 the compounds of examples 2 to 12 were prepared.

1. customUsual workup, flash-chromatography (silica, eluent dichloromethane/methanol) and final evaporation of the solvent