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HRID1181198

反应详情

EQUATION

反应方程式

HRID 1181198 的结构方程式

REACTANTS

反应物

3
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：Nc1ncnc2c1nc(Br)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
HCID96544

8-Bromoadenosine

C10H12BrN5O4

结构：NCCP(=O)([O-])[O-]
HCID23421211

未命名化合物

PRODUCTS

生成物

1
结构：Nc1ncnc2c1nc(NCCP(=O)(O)O)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
HCID44591721

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.O
溶剂HCID19096565

未命名化合物

CONDITIONS

反应条件

温度
110 °C

PROCEDURE

实验过程

A mixture of 8-bromoadenosine (1 mmol), aminoethylphosphonate (2 mmol), and sodium hydroxide (2 mmol) in ethanol-water in a sealed tube was warmed at 110° C. under nitrogen. After 24 h the cooled reaction mixture was purified through preparative HPLC to give 8-(2-phosphonoethylamino)-adenosine (4.1). mp 175° C.;

WORKUP

后处理

  1. customAfter 24 h the cooled reaction mixture
  2. customwas purified through preparative HPLC