HuagongsheHuagongshe Chemistry Print Report · For research reference only
N9-phenethyl-8-bromomethyladenine → N9-phenethyl-8-diethylphosphonomethoxymethyladenine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N9-phenethyl-8-bromomethyladenine | HCID 42637845 | — |
| Reactant | Diethyl hydroxymethylphosphonate sodium salt | HCID 86585098 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N9-phenethyl-8-diethylphosphonomethoxymethyladenine | HCID 42637083 | — |
Reaction Steps
A solution of N9-phenethyl-8-bromomethyladenine (1 mmol) in DMF was treated with a solution of diethyl hydroxymethylphosphonate sodium salt (1 mmol) in DMF at 25° C. for 1 h. Extraction and chromatography gave N9-phenethyl-8-diethylphosphonomethoxymethyladenine as a white solid. TLC: Rf=0.31, 10% MeOH—CH2Cl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07285543B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-f5f1d6e621cc40db8bf32fdae432bb69 |
| Source note | uspto-grants-2007_10 |