Pyridine → HCID 86602091, compound

HRID 1181202Notes

Reaction equation

HRID 1181202 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[C:3]=1N.[N:15]1C=CC=CC=1.[C:21]([O:24][CH2:25][C:26](Cl)=[O:27])(=[O:23])[CH3:22]>C(OCC)C>[Cl:1][C:2]1[N:7]=[C:6]([NH2:15])[N:5]=[C:4]([NH:8][CH2:9][C:10]([CH3:11])([CH3:12])[CH3:13])[C:3]=1[C:26](=[O:27])[CH2:25][O:24][C:21](=[O:23])[CH3:22]

Participants

5

Reactant 3

HCID 1049PyridineHCID 26297Acetoxyacetyl chlorideHCID 22274990HCID 22274990, compound

Product 1

HCID 86602091HCID 86602091, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 6-chloro-5-amino-4-(neopentylamino)pyrimidine (1 mmol) in diethyl ether was treated with pyridine (3 mmol), and acetoxyacetyl chloride (1.2 mmol) at 25° C. for 12 h. Extraction and chromatography afforded 6-chloro-5-acetoxyacetyl-amino-4-neopentylaminopyrimidine as a yellow solid. TLC: Rf=0.18, 30% EtOAc-hexane.

Workup

  1. extractionExtraction and chromatography

Sources & evidence

ORD record
ord-a88078b31efc45c0a3aa0d2ce2733f8b
Source dataset
uspto-grants-2007_10
Patent number
US07285543B2

Reaction notes

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