Sodium Hydroxide → HCID 54539253, compound

HRID 1181203Notes

Reaction equation

HRID 1181203 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([CH2:16][O:17]C(=O)C)[N:6]2[CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13].[OH-].[Na+]>C1COCC1.O>[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([CH2:16][OH:17])[N:6]2[CH2:11][C:12]([CH3:13])([CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54013252HCID 54013252, compound

Product 1

HCID 54539253HCID 54539253, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

A solution of 6-chloro-8-acetoxymethyl-N9-neopentylpurine (1 mmol) in THF-water was treated with aqueous sodium hydroxide (1.5 mmol) at 0° C. for 0.5 h. Extraction and chromatography afforded 6-chloro-8-hydroxymethyl-N9-neopentylpurine as a yellow gel. TLC: Rf=0.38, 33% EtOAc-hexane.

Workup

  1. extractionExtraction and chromatography

Sources & evidence

ORD record
ord-6220e59b8a7e48538a97f5664ca1474c
Source dataset
uspto-grants-2007_10
Patent number
US07285543B2

Reaction notes

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