Phosphorus tribromide → HCID 53929309, compound

HRID 1181204Notes

Reaction equation

HRID 1181204 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([CH2:16]O)[N:6]2[CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13].P(Br)(Br)[Br:19]>C(Cl)Cl>[Cl:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([CH2:16][Br:19])[N:6]2[CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 54539253HCID 54539253, compound

Product 1

HCID 53929309HCID 53929309, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 6-chloro-8-hydroxymethyl-N9-neopentylpurine (1 mmol) in methylene chloride was treated with phosphorus tribromide (1 mmol) at 25° C. for 6 h. Extraction and chromatography afforded 6-chloro-8-bromomethyl-N9-neopentylpurine as a white solid. TLC: Rf=0.64, 25% EtOAc-hexane.

Workup

  1. extractionExtraction and chromatography

Sources & evidence

ORD record
ord-4b0f9106c5ee4b5a8720fe66b38791ce
Source dataset
uspto-grants-2007_10
Patent number
US07285543B2

Reaction notes

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