HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl chlorophosphate → 1-Benzyl-2-diethylphosphonoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl chlorophosphate | HCID 13139 | — |
| Reactant | 1-Benzylimidazole | HCID 77918 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzyl-2-diethylphosphonoimidazole | HCID 42637146 | — |
Reaction Steps
A solution of 1-benzylimidazole (1.1 mmol) in THF was treated with LDA (1.1 mmol) at −78° C. for 1 h, and followed by addition of diethyl chlorophosphate (2 mmol), and stirred for 2 h. Extraction and chromatography gave 1-benzyl-2-diethylphosphonoimidazole as a yellow oil. TLC: Rf=0.35, 80% EtOAc-hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07285543B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-257642a8c64c42ba97979f3cf0ecdc75 |
| Source note | uspto-grants-2007_10 |