HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 2-Amino-4-chloro-6-neopentylpyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| Edukt | Neopentylamine | HCID 79882 | — |
| Lösungsmittel | 1-Butanol | HCID 263 | — |
| Produkt | 2-Amino-4-chloro-6-neopentylpyrimidine | HCID 22274982 | — |
Reaktionsschritte
A solution of 2-amino-4,6-dichloropyrimidine (1 mmol), neopentylamine (1.05 mmol), and triethylamine (2 mmol) in n-butanol was stirred at 110° C. for 12 h. Extraction and chromatography gave 2-amino-4-chloro-6-neopentylpyrimidine as a yellow solid. TLC: Rf=0.2, 30% EtOAc-hexane.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07285543B2 |
| Quelldatensatz | uspto-grants-2007_10 |
| ORD ID | ord-cf023552cadf4738bc4cf9fc56aeccc5 |
| Quellennotiz | uspto-grants-2007_10 |