HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1181213Generated: October 25, 2026
Acetic Acid → 4-Chloro-2,5-diamino-6-neopentyl-pyrimidine
https://huagongshe.com/reaction/1181213
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Benzenediazonium, 4-chloro-, hexafluorophosphate(1-) (1:1) | HCID 2723983 | — |
| Reactant | 2-Amino-4-chloro-6-neopentylpyrimidine | HCID 22274982 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 4-Chloro-2,5-diamino-6-neopentyl-pyrimidine | HCID 22274946 | — |
Reaction Steps
A mixture of 2-amino-4-chloro-6-neopentylpyrimidine (1 mmol), sodium acetate (14 mmol), acetic acid (86 mmol), and 4-chlorobenzene-diazonium hexafluorophosphate (1.15 mmol) in water was stirred at 25° C. for 12 h. Extraction and evaporation gave a yellow solid which was treated with zinc dust (10 mmol) and acetic acid (5.54 mmol) in EtOH-H2O at 80° C. for 1 h. Extraction and chromatography gave 4-chloro-2,5-diamino-6-neopentyl-pyrimidine as a yellow solid. TLC: Rf=0.25, 50% EtOAc-hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07285543B2 |
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| Source dataset | uspto-grants-2007_10 |
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| ORD ID | ord-09ffa72cb21047dd815f426161ecb07a |
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| Source note | uspto-grants-2007_10 |
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