HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Amino-4-chloro-6-neopentylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| Reactant | Neopentylamine | HCID 79882 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 2-Amino-4-chloro-6-neopentylpyrimidine | HCID 22274982 | — |
Reaction Steps
A solution of 2-amino-4,6-dichloropyrimidine (1 mmol), neopentylamine (1.05 mmol), and triethylamine (2 mmol) in n-butanol was stirred at 110° C. for 12 h. Extraction and chromatography gave 2-amino-4-chloro-6-neopentylpyrimidine as a yellow solid. TLC: Rf=0.2, 30% EtOAc-hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07285543B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-9feb5e4a24f44f44a571ae7985cb2fb4 |
| Source note | uspto-grants-2007_10 |