HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-chloropyrimidine → HCID 21041370, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| Reactant | Benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy) pyrimidin-4-yl]-amide | HCID 21041229 | — |
| Product | HCID 21041370 | HCID 21041370 | 48.4% |
Reaction Steps
Benzylsulfamic acid [6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-chloro-5-methoxy-phenoxy)-pyrimidin-4-yl]-amide (77 mg) (Example 212) was prepared from benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy)-pyrimidin-4-yl]-amide (120 mg) (Example 211) and 5-bromo-2-chloropyrimidine (100 mg) according to the procedure described in Example 14. LC-MS: tR=5.29; [M+H]+=639.04.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07285549B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-481749605076495abe53638ccc865b1f |
| Source note | uspto-grants-2007_10 |