2-(Furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine → HCID 11351635, compound

Participants

Reaction Steps

2-Furan-2-yl-5-methanesulfonyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine (0.15 mmol; see Example 1(a) above) was suspended in 4 mL of CH3CN along with 3 eq. of (3,5-Dichloro-pyridin-4-yl)-piperazin-1-yl-methanone. The reaction mixture was stirred under reflux for 3 hours. It was then cooled to room temperature and concentrated under reduced pressure. The resulting crude product was purified by preparative HPLC using a mixture of aqueous CH3CN that has been buffered with 0.1% TFA. 1H NMR (DMSO-d6) δ 8.9 (s, 2H), 7.60 (d, J=1.0 Hz, 1H), 7.28 (br s, 2H), 7.22 (d, J=3.6 Hz, 1H), 6.68 (dd, J=3.6 Hz, 1.0 Hz, 1H), 2.2-3.2 (m, 8H). MS: m/z: 461 [M+H]+.

Provenance & Evidence