Triethylamine → HCID 69432731, compound

Participants

Reaction Steps

2-Chloromethyl-pyridine (1.5 eq.) was directly added to a solution of 5-[1,4]diazepan-1-yl-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine (0.14 mmol; see Example 8(a) above) and Et3N (0.3 mmol) in 3 mL of CH3CN. The resulting reaction mixture was stirred at room temp for 18 hours. It was then concentrated and purified by preparative HPLC using a mixture of aqueous CH3CN that has been buffered with 0.1% TFA. 1H NMR (DMMSO-d6) δ 7.60 (d, J=1.0 Hz, 1H), 7.28 (br s, 2H), 7.22 (d, J=3.6 Hz, 1H), 6.9-7.1 (m, 4H), 6.68 (dd, J=3.6 Hz, 1.0 Hz, 1H); 3.8 (br s, 2H), 2.2-3.2 (m, 10 H). MS: m/z: 392 [M+H]+.

Provenance & Evidence