2-(Furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine → 7-Furan-2-yl-N2-pyrrolidin-2-ylmethyl-pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine

HRID 1181304Notes

Reaction equation

HRID 1181304 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:29]=[C:9]2[N:10]=[C:11]([N:15]3[CH2:21][CH2:20][CH2:19][N:18](CC4C=C(C)ON=4)[CH2:17][CH2:16]3)[N:12]=[C:13]([NH2:14])[N:8]2[N:7]=1.O1C=CC=C1C1C=C2N=C(S(C)(=O)=O)N=C(N)N2N=1.O1C=CC=C1C1N=C2N=C(S(C)(=O)=O)N=C(N)N2N=1>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:29]=[C:9]2[N:10]=[C:11]([NH:15][CH2:16][CH:17]3[CH2:21][CH2:20][CH2:19][NH:18]3)[N:12]=[C:13]([NH2:14])[N:8]2[N:7]=1

Participants

4

Reactant 3

HCID 99708822-(Furan-2-yl)-5-(methylsulfonyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amineHCID 111768787-Furan-2-yl-2-[4-(5-methyl-isoxazol-3-ylmethyl)-[1,4]diazepan-1-yl]-pyrazolo[1,5-a][1,3,5]triazin-4-ylamineHCID 157300647-Furan-2-yl-2-methanesulfonyl-pyrazolo[1,5-a][1,3,5]triazin-4-ylamine

Product 1

HCID 694307307-Furan-2-yl-N2-pyrrolidin-2-ylmethyl-pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine

Procedure

7-Furan-2-yl-N2-pyrrolidin-2-ylmethyl-pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine was prepared in the same manner as described in Example 6(a) and (b) above, except that 7-furan-2-yl-2-methanesulfonyl-pyrazolo[1,5-a][1,3,5]triazin-4-ylamine was used as the starting material instead of 2-furan-2-yl-5-methanesulfonyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine.

Sources & evidence

ORD record
ord-062b70df385245e29e01396c680fc586
Source dataset
uspto-grants-2007_10
Patent number
US07285550B2

Reaction notes

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