1-Boc-3-(aminomethyl)piperidine → 2-Furan-2-yl-N5-piperidin-3-ylmethyl-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

HRID 1181308Notes

Reaction equation

HRID 1181308 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:28]=[C:9]2[N:10]=[C:11]([N:15](C)[CH2:16][CH2:17]N(C)CC3C=C(C)ON=3)[N:12]=[C:13]([NH2:14])[N:8]2[N:7]=1.N[CH2:30][CH:31]1CC[CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32]1.NCC1CCCN1C(OC(C)(C)C)=O>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:28]=[C:9]2[N:10]=[C:11]([NH:15][CH2:16][CH:17]3[CH2:30][CH2:31][CH2:32][NH:33][CH2:34]3)[N:12]=[C:13]([NH2:14])[N:8]2[N:7]=1

Participants

4

Reactant 3

HCID 27564831-Boc-3-(aminomethyl)piperidineHCID 2756484(+-)-2-(Aminomethyl)-1-N-Boc-pyrrolidineHCID 112575762-Furan-2-yl-N5-methyl-N5-{2-[methyl-(5-methyl-isoxazol-3-ylmethyl)-amino]-ethyl}-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

Product 1

HCID 694352252-Furan-2-yl-N5-piperidin-3-ylmethyl-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

Procedure

2-Furan-2-yl-N5-piperidin-3-ylmethyl-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine was prepared in the same manner as described in Example 6(a) and (b) above, except that 3-aminomethyl-1-Boc-piperidine was used as the starting material instead of 2-aminomethyl-1-Boc-pyrrolidine (both starting materials are commercially available from Astatech, Monmouth Junction, N.J.).

Sources & evidence

ORD record
ord-bccdd4c41a8f4d9e8225e1ada21a8d1f
Source dataset
uspto-grants-2007_10
Patent number
US07285550B2

Reaction notes

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