Water → 2-Bromo-5-methoxybenzaldehyde

HRID 1181327Notes

Reaction equation

HRID 1181327 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7].[Br:11]Br.O>C(O)(=O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[CH:6]=[O:7]

Participants

5

Reactant 3

HCID 962WaterHCID 115693-MethoxybenzaldehydeHCID 24408Bromine

Product 1

HCID 3444802-Bromo-5-methoxybenzaldehydeYield 88%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

3-Methoxybenzaldehyde (15 g) was dissolved in acetic acid (75 ml), and a solution of bromine (5.7 ml) dissolved in acetic acid (15 ml) was added dropwise. The mixture was stirred overnight at room temperature and water (150 ml) was added to the reaction mixture. The precipitated crystals were collected by filtration, washed with water and dried under reduced pressure to give the title compound (21 g, yield 88%).

Workup

  1. additionwas added dropwise
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-23de7edd12e2411b9f0c24c9a9ffe459
Source dataset
uspto-grants-2007_10
Patent number
US07285551B2

Reaction notes

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