Sodium Hydroxide → HCID 58980880, compound

HRID 1181375Notes

Reaction equation

HRID 1181375 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:18][C:17]3[C:16](=[O:19])[N:15]([C:20]4[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]5[CH2:33][CH2:32][CH2:31][CH2:30]5)=[C:22]([O:34][CH3:35])[CH:21]=4)C=[N:13][C:12]=3[CH:11]=2)=[CH:6][CH:5]=1>CS(C)=O>[NH2:13][C:12]1[CH:11]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=2)[S:18][C:17]=1[C:16]([NH:15][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[C:22]([O:34][CH3:35])[CH:21]=1)=[O:19]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9826520GW-803430

Product 1

HCID 58980880HCID 58980880, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Aqueous NaOH (4 mL, 1N) was added to a DMSO solution of 6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl] thieno[3,2-d]pyrimidin-4(3H)-one (0.50 g, 0.001 mol) at 170° C. After 5 minutes a gummy precipitate was triturated with water and solidified to a tan solid (0.30 g, 60%).

Workup

  1. customAfter 5 minutes a gummy precipitate was triturated with water

Sources & evidence

ORD record
ord-58a0e9bd69a745c0afb20ee1480922bc
Source dataset
uspto-grants-2007_10
Patent number
US07285557B2

Reaction notes

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