HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(2-Benzyl-1,3-thiazol-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Benzyl-4-chloromethylthiazole | HCID 3015874 | — |
| Product | 1-(2-Benzyl-1,3-thiazol-4-yl)methanamine | HCID 20982896 | 50% |
Reaction Steps
2-Benzyl-4-chloromethylthiazole [Pharmazie 1972, 27, 146] (223.7 g, 1 mol) was stirred with liquid ammonia (600 ml) in an autoclave for 24 hours. The ammonia was removed and the product was distilled in vacuo [bp (0.02 mmHg) 141-144° C.] to give the title compound (102 g, 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07285563B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-57c04ec346d14abe86301c57106f7f6a |
| Source note | uspto-grants-2007_10 |