反应详情

To a solution of 2-nitro-4-(trifluoromethyl)benzonitrile (22.48 g, 104 mmol) in anhydrous methanol (110 ml) was added dropwise 25% sodium methoxide in methanol (24.72 ml, 114.4 mmol), and the resulting mixture stirred at room temperature for 1 hour. Water (110 ml) was added and the resulting solids collected by filtration. The solids were dissolved in DCM (150 ml), washed with sat NaCl (75 ml), dried over Na2SO4, filtered and evaporated to give the title compound (19 g, 91%) as a white solid.

1. filtrationthe resulting solids collected by filtration
2. dissolutionThe solids were dissolved in DCM (150 ml)
3. washwashed with sat NaCl (75 ml)
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated