6-Aminoisoquinoline → N-Isoquinolin-6-yl-N'-[4-(trifluoromethyl)benzyl]urea

HRID 1181448Notes

Reaction equation

HRID 1181448 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][CH:6]=[CH:5]2.[F:12][C:13]([F:25])([F:24])[C:14]1[CH:23]=[CH:22][C:17]([CH2:18][N:19]=[C:20]=[O:21])=[CH:16][CH:15]=1>>[CH:8]1[C:9]2[C:4](=[CH:3][C:2]([NH:1][C:20]([NH:19][CH2:18][C:17]3[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:25])[F:24])=[CH:23][CH:22]=3)=[O:21])=[CH:11][CH:10]=2)[CH:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 5889916-AminoisoquinolineHCID 223376994-(Trifluoromethyl)benzyl isocyanate

Product 1

HCID 69522788N-Isoquinolin-6-yl-N'-[4-(trifluoromethyl)benzyl]urea

Procedure

Prepared from 6-aminoisoquinoline (Description 51) and [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to the procedure of Description 61. m/z (ES+) 346 (M+H)+.

Sources & evidence

ORD record
ord-d048ac942ea145519d229363be523de5
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

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