4-(Trifluoromethyl)benzyl isocyanate → N-(6-Fluoro-3-methylisoquinolin-5-yl)-N'-[4-(trifluoromethyl)benzyl]urea

HRID 1181479Notes

Reaction equation

HRID 1181479 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]2[CH:8]=[N:7][C:6]([CH3:12])=[CH:5][C:4]=2[C:3]=1[NH2:13].[F:14][C:15]([F:27])([F:26])[C:16]1[CH:25]=[CH:24][C:19]([CH2:20][N:21]=[C:22]=[O:23])=[CH:18][CH:17]=1>>[F:1][C:2]1[C:3]([NH:13][C:22]([NH:21][CH2:20][C:19]2[CH:18]=[CH:17][C:16]([C:15]([F:14])([F:27])[F:26])=[CH:25][CH:24]=2)=[O:23])=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][C:6]([CH3:12])=[CH:5]2

Participants

3

Reactant 2

HCID 223376994-(Trifluoromethyl)benzyl isocyanateHCID 673632546-Fluoro-3-methylisoquinolin-5-amine

Product 1

HCID 69523215N-(6-Fluoro-3-methylisoquinolin-5-yl)-N'-[4-(trifluoromethyl)benzyl]urea

Procedure

Prepared from 6-fluoro-3-methylisoquinolin-5-amine (Description 79) and [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to Description 61. m/z (ES+) 378 (M+H)+.

Sources & evidence

ORD record
ord-3f54f6d1d29b43b2a538fc387867b2ea
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

Loading…