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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1181495Generated: October 25, 2026

4-(Trifluoromethyl)benzyl isocyanate → N-[1-(Methoxycarbonyl)isoquinolin-5-yl]-N'-[4-(trifluoromethyl)benzyl]urea

https://huagongshe.com/reaction/1181495

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzyl isocyanateHCID 22337699—
ReactantMethyl 5-aminoisoquinoline-1-carboxylateHCID 45089622—
ProductN-[1-(Methoxycarbonyl)isoquinolin-5-yl]-N'-[4-(trifluoromethyl)benzyl]ureaHCID 69522898—

Reaction Steps

Prepared from methyl 5-aminoisoquinoline-1-carboxylate (Description 106) and [4-(trifluoromethyl)benzyl]isocyanate (description 58) according to the procedure of description 61. m/z (ES+) 404 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07285563B2
Source datasetuspto-grants-2007_10
ORD IDord-753ae262985e423e8fbfb03c5ab9b6e8
Source noteuspto-grants-2007_10