HCID 10725908, compound → HCID 69523555, compound

HRID 1181500Notes

Reaction equation

HRID 1181500 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[CH:11]=[N:10][CH:9]=[CH:8][C:7]=2[C:6]([NH2:13])=[CH:5][CH:4]=1.COC1C=CC([N+]([O-])=O)=C2C=1C=NC=C2.[F:29][C:30]([F:42])([F:41])[C:31]1[CH:40]=[CH:39][C:34]([CH2:35][N:36]=[C:37]=[O:38])=[CH:33][CH:32]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:13][C:37]([NH:36][CH2:35][C:34]2[CH:33]=[CH:32][C:31]([C:30]([F:29])([F:42])[F:41])=[CH:40][CH:39]=2)=[O:38])=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2

Participants

4

Reactant 3

HCID 10725908HCID 10725908, compoundHCID 21599337HCID 21599337, compoundHCID 223376994-(Trifluoromethyl)benzyl isocyanate

Product 1

HCID 69523555HCID 69523555, compound

Procedure

Prepared from 8-methoxyisoquinolin-5-amine which was prepared from 8-methoxy-5-nitroisoquinoline (J. Het. Chem. 37(5), 1293) according to Description 43 and immediately used in reaction with [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to Description 61. m/z (ES+) 376 (M+H)+.

Sources & evidence

ORD record
ord-7b0a59cf849b43b3b723ccf8f1d0b63a
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

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