反应详情

A solution of 1-benzyl-4-(N-tert-butoxycarbonyl-N-isopropylamino)piperidine (79.0 g, 0.24 mol) in ethanol (140 mL) was flushed with nitrogen for 15 minutes. This solution was then added to a 2 L Parr flask containing a mixture of 10% palladium on carbon (15.8 g; ca. 50% wt. water) in ethanol (100 mL), which solution had been flushed with nitrogen for 15 minutes. This reaction mixture was placed on a Parr Shaker under hydrogen at 50 psi for 24 hours. The reaction mixture was filtered through a pad of Celite and the Celite washed with ethanol. The filtrate was then concentrated in vacuo to afford 57.0 g of the title intermediate as a white solid (>99% yield).

1. additionThis solution was then added to a 2 L Parr flask
2. additioncontaining
3. customhad been flushed with nitrogen for 15 minutes
4. filtrationThe reaction mixture was filtered through a pad of Celite
5. washthe Celite washed with ethanol
6. concentrationThe filtrate was then concentrated in vacuo