Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | HCID 58981192 | HCID 58981192 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10392826 | HCID 10392826 | — |
Reaction Steps
200 mg of the acid 48 were dissolved in 2 ml of absolute DMF. 94 mg of HOAt and 158 μl of DIEA were added. 56 μl of ethanolamine were then added dropwise and the mixture was cooled down to 0° C.; 195 mg of EDC were then added. After 2 days of stirring at room temperature, the solvent was evaporated and the crude product was purified by means of MPLC (eluent: DCM:MeOH=9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07285560B2 |
|---|
| Source dataset | uspto-grants-2007_10 |
|---|
| ORD ID | ord-9169390c51e7457fbdd5cac859b4225d |
|---|
| Source note | uspto-grants-2007_10 |
|---|
