HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1181577Generated: November 3, 2026
5-Ethyl-2-(1-hydroxy-ethyl)-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one → 2-Acetyl-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one
https://huagongshe.com/reaction/1181577
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Ethyl-2-(1-hydroxy-ethyl)-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one | HCID 69402313 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Acetyl-5-ethyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one | HCID 69402667 | 90% |
Reaction Steps
5-Ethyl-2-(1-hydroxy-ethyl)-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (13 g, 47.6 mmol) and manganese(IV)dioxide (16.54 g, 190 mmol) were suspended in chloroform (400 mL) and stirred at 65° C. for 16 h. The mixture was cooled, filtered over Celite and the filtrate concentrated in vacuo yielding 11.6 g (90%) of a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07285569B2 |
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| Source dataset | uspto-grants-2007_10 |
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| ORD ID | ord-c7f86cc9f343413889f43923ba7ad516 |
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| Source note | uspto-grants-2007_10 |
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