Sodium Hydroxide → HCID 11203030, compound

Participants

Reaction Steps

ethyl [2′-[(1R)-1-[(2R)-2-Hydroxy-3-[[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino]propoxy]ethyl]biphenyl-3-yl]acetate (400 mg) obtained in Step 3 was dissolved in methanol (2 ml) and tetrahydrofuran (4 ml), 1N-aqueous sodium hydroxide (1.5 ml) was added, and the mixture was stirred at room temperature for 6 hr. The reaction mixture was concentrated under reduced pressure. The obtained residue was diluted with water and neutralized with 10% aqueous citric acid. The precipitated white solid was collected by filtration and dried in vacuo to give the title compound (325mg).

Provenance & Evidence