Water → HCID 178467902, compound

Participants

Reaction Conditions

Reaction Steps

2′-[1-[(2R)-2-Hydroxy-3-[[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino]propoxy]ethyl]biphenyl-4-carbonitrile (500 mg) obtained in Step 2 was dissolved in N,N-dimethylformamide (6.0 ml), ammonium chloride (535 mg) and sodium azide (676 mg) were successively added and the mixture was stirred overnight at 115° C. Water was added to the reaction mixture, and the precipitated solid was collected by filtration. The solid was dissolved in methanol, water was added and the mixture was concentrated under reduced pressure. The precipitated solid was collected by filtration to give the title compound (280 mg).

Provenance & Evidence