Citric Acid → HCID 53318971, compound

Participants

Reaction Conditions

Reaction Steps

2′-[1-[(2R)-2-Hydroxy-3-[[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino]propoxy]ethyl]biphenyl-4-carbonitrile (1.0 g) obtained in Example 7, Step 2 was dissolved in ethylene glycol (15 ml). Potassium hydroxide (2.76 g) was added and the mixture was stirred overnight at 160° C. The reaction mixture was allowed to return to room temperature, a small amount of water was added and 10% aqueous citric acid was added to adjust the mixture to pH 4-5. The precipitated solid was collected by filtration to give the title compound (924 mg).

Provenance & Evidence