Citric Acid → HCID 23111629, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 5-(2-acetylphenyl)thiophene-2-carboxylate (3.52 g) obtained in Step 2 was dissolved in ethanol (30 ml) and the mixture was cooled to 0° C. Sodium borohydride was added and the mixture was stirred overnight at 0° C.—room temperature. The reaction mixture was cooled to 0° C., 10% aqueous citric acid was added dropwise and ethanol was evaporated. The reaction mixture was extracted with ethyl acetate, washed successively with water, saturated aqueous sodium hydrogencarbonate and brine, and dried over sodium sulfate. The organic layer was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to give the title compound (3.30 g).

Provenance & Evidence