Potassium Carbonate → 3-[7-[(3,5-dimethylisoxazol-4-yl)methyl]-5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]benzoic acid

HRID 1181681ノート

反応式

HRID 1181681 の反応式
Cl[CH2:2][C:3]1[C:4]([CH3:9])=[N:5][O:6][C:7]=1[CH3:8].[CH3:10][N:11]1[C:16](=[O:17])[C:15]2=[C:18]([C:32]3[CH:33]=[C:34]([CH:38]=[CH:39][CH:40]=3)[C:35]([OH:37])=[O:36])[N:19]([CH2:21][C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH:25]=[CH:24][CH:23]=3)[N:20]=[C:14]2[NH:13][C:12]1=[O:41].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:9][C:4]1[C:3]([CH2:2][N:13]2[C:14]3=[N:20][N:19]([CH2:21][C:22]4[C:31]5[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=5)[CH:25]=[CH:24][CH:23]=4)[C:18]([C:32]4[CH:33]=[C:34]([CH:38]=[CH:39][CH:40]=4)[C:35]([OH:37])=[O:36])=[C:15]3[C:16](=[O:17])[N:11]([CH3:10])[C:12]2=[O:41])=[C:7]([CH3:8])[O:6][N:5]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-HCID 1363341153-[5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]benzoic acid

生成物 1

HCID 589810443-[7-[(3,5-dimethylisoxazol-4-yl)methyl]-5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]benzoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
85 °C

実験手順

4-(chloromethyl)-3,5-dimethylisoxazole (0.145 g) was added to a suspension of Resin bound 3-[5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]benzoic acid (0.120 g) and potassium carbonate (0.397 g) in dimethylformamide (1 ml). Reaction mixture was shaken at 85° C. for 20 hours. The resin was filtered and washed (3 times) DMF, H2O, DMF, CH2Cl2, MeOH, CH2Cl2, and dried in vacuum to give the subtitle compound.

後処理

  1. customReaction mixture
  2. filtrationThe resin was filtered
  3. washwashed (3 times) DMF, H2O, DMF, CH2Cl2, MeOH, CH2Cl2
  4. customdried in vacuum

出典と根拠

ORDレコード
ord-0c1d276037f241ebb8bac85f0f991fd6
出典データセット
uspto-grants-2007_10
特許番号
US07285558B2

反応ノート

読み込み中…