Acetic Acid → 7-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

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Reaction Steps

1-naphthaldehyde (3-isobutyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)hydrazone (3.4 g) was dissolved in a solution of dimethylformamide (99 ml) and isopropanol (24 ml). isonicotinaldehyde (1.3 g) was added followed by piperidine (0.99 ml) and acetic acid (0.12 ml) The mixture was stirred at room temperature for 18 hours. Solvents were removed under reduced pressure. Crude residue was crystallized in methanol/water to give the title compound (3.28 g). Mass: 425.95 (M+H).

Provenance & Evidence