HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1181685Generated: October 31, 2026
Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 7-Isobutyl-5-(2-morpholin-4-ylethyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
https://huagongshe.com/reaction/1181685
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 7-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | HCID 69427445 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Isobutyl-5-(2-morpholin-4-ylethyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | HCID 58980914 | 91.1% |
Reaction Steps
4-(2-chloroethyl)morpholine hydrochloride (0.0435 g) followed by DBU (0.094 g) were added to a solution of 7-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (0.0668 g) in dimethylformamide (1 ml). The mixture was heated at 80° C. for 18 hours then cooled to room temperature. The crude reaction was purified on preparative HPLC to give the title compound (0.077 g). Mass: 538.90 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07285558B2 |
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| Source dataset | uspto-grants-2007_10 |
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| ORD ID | ord-f253712b955c4370ae2ee2831182f521 |
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| Source note | uspto-grants-2007_10 |
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