6-Chloroquinoline-4-carbaldehyde → HCID 24884488, compound

HRID 1181688Notes

Reaction equation

HRID 1181688 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10]([NH:11][NH2:12])=[CH:9][C:8](=[O:13])[N:7]([CH3:14])[C:6]2=[O:15])[CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[C:20]2[CH:27]=O.[CH:29]([C:31]1[N:35]([CH3:36])[CH:34]=[C:33]([C:37]#[N:38])[CH:32]=1)=O>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[C:20]2[CH2:27][N:12]1[C:29]([C:31]2[N:35]([CH3:36])[CH:34]=[C:33]([C:37]#[N:38])[CH:32]=2)=[C:9]2[C:10]([N:5]([CH2:4][CH:1]3[CH2:2][CH2:3]3)[C:6](=[O:15])[N:7]([CH3:14])[C:8]2=[O:13])=[N:11]1

Participants

4

Reactant 3

HCID 31460316-Chloroquinoline-4-carbaldehydeHCID 12730477HCID 12730477, compoundHCID 694271711-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 24884488HCID 24884488, compound

Procedure

This compound was made following the procedure described above, startng with 1-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione synthesized according to the procedure used in example 1 for the corresponding isobutyl substituted compound, and condensing first with 6-chloroquinoline-4-carbaldehyde, followed by 5-formyl-1-methyl-1H-pyrrole-3-carbonitrile. Mass: 500.11 (M+H).

Workup

  1. customsynthesized

Sources & evidence

ORD record
ord-464097044ab042bda84fdcd6aedf5d47
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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