6-Chloroquinoline-4-carbaldehyde → 3-(4-acetyl-1-methyl-1H-pyrrol-2-yl)-2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1181745
[CH:1]1([CH2:4][N:5]2[C:10]([NH:11][NH2:12])=[CH:9][C:8](=[O:13])[N:7]([CH3:14])[C:6]2=[O:15])[CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[C:20]2[CH:27]=O.[C:29]([C:32]1[CH:33]=[C:34]([CH:38]=O)[N:35]([CH3:37])[CH:36]=1)(=[O:31])[CH3:30]>>[C:29]([C:32]1[CH:33]=[C:34]([C:38]2[N:12]([CH2:27][C:20]3[C:19]4[C:24](=[CH:25][CH:26]=[C:17]([Cl:16])[CH:18]=4)[N:23]=[CH:22][CH:21]=3)[N:11]=[C:10]3[C:9]=2[C:8](=[O:13])[N:7]([CH3:14])[C:6](=[O:15])[N:5]3[CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:35]([CH3:37])[CH:36]=1)(=[O:31])[CH3:30]

Komponenten

4

Edukt 3

HCID 31460316-Chloroquinoline-4-carbaldehydeHCID 126762684-Acetyl-1-methyl-1H-pyrrole-2-carbaldehydeHCID 694271711-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 589811863-(4-acetyl-1-methyl-1H-pyrrol-2-yl)-2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Versuchsvorschrift

This compound was made following the procedure described above, starting with 1-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first with 6-chloroquinoline-4-carbaldehyde, followed by 4-acetyl-1-methyl-1H-pyrrole-2-carbaldehyde. Mass: 517.14 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-c578b4c5aaab4c30b3dba60ea493dd6e
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285558B2

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