1-Methyl-2-imidazolecarboxaldehyde → 7-isobutyl-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2-[(5-methyl-1H-indol-3-yl)methyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1181751
[NH:1]([C:3]1[N:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7](=[O:13])[N:6]([CH3:14])[C:5](=[O:15])[CH:4]=1)[NH2:2].[CH3:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][CH:21]=[C:20]2[CH:26]=O.[CH3:28][N:29]1[CH:33]=[CH:32][N:31]=[C:30]1[CH:34]=O>>[CH2:9]([N:8]1[C:3]2=[N:1][N:2]([CH2:26][C:20]3[C:19]4[C:23](=[CH:24][CH:25]=[C:17]([CH3:16])[CH:18]=4)[NH:22][CH:21]=3)[C:34]([C:30]3[N:29]([CH3:28])[CH:33]=[CH:32][N:31]=3)=[C:4]2[C:5](=[O:15])[N:6]([CH3:14])[C:7]1=[O:13])[CH:10]([CH3:11])[CH3:12]

Komponenten

4

Edukt 3

HCID 1395751-Methyl-2-imidazolecarboxaldehydeHCID 2591875-Methylindole-3-carboxaldehydeHCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 589809687-isobutyl-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2-[(5-methyl-1H-indol-3-yl)methyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Versuchsvorschrift

This compound was made following the procedure described above, starting with 6-hydrazino-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first with 5-methyl-1H-indole-3-carbaldehyde, followed by 1-methyl-1H-imidazole-2-carbaldehyde. Mass: 446.26 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-017c6d96ad904543bfa1a4662addb17a
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285558B2

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