HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Xylyl bromide → 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-7-(2-methylbenzyl)-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Xylyl bromide | HCID 6992 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | HCID 136334114 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-7-(2-methylbenzyl)-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | HCID 58980936 | — |
Reaction Steps
This compound was synthesized by the reaction of 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione and 1-(bromomethyl)-2-methylbenzene using DBU as a base in DMF at 80° C., Mass: 514.11 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07285558B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-fbc7a12452a947b8a45b25b7a8e9744b |
| Source note | uspto-grants-2007_10 |