Trifluoroacetic acid → 3-(4-amino-1-methyl-1H-imidazol-2-yl)-2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181783노트

반응식

HRID 1181783 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[CH2:12][N:13]1[C:21]([C:22]2[N:23]([CH3:35])[CH:24]=[C:25]([NH:27]C(=O)OC(C)(C)C)[N:26]=2)=[C:20]2[C:15]([N:16]([CH2:39][CH:40]3[CH2:42][CH2:41]3)[C:17](=[O:38])[N:18]([CH3:37])[C:19]2=[O:36])=[N:14]1.C(O)(C(F)(F)F)=O>ClCCl>[NH2:27][C:25]1[N:26]=[C:22]([C:21]2[N:13]([CH2:12][C:5]3[C:4]4[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=4)[N:8]=[CH:7][CH:6]=3)[N:14]=[C:15]3[C:20]=2[C:19](=[O:36])[N:18]([CH3:37])[C:17](=[O:38])[N:16]3[CH2:39][CH:40]2[CH2:41][CH2:42]2)[N:23]([CH3:35])[CH:24]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69426445tert-butyl 2-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-imidazol-4-ylcarbamate

생성물 1

HCID 589810593-(4-amino-1-methyl-1H-imidazol-2-yl)-2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

This compound was synthesized by treating tert-butyl 2-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-imidazol-4-ylcarbamate with 10% TFA in dichloromethane at room temperature for 5 hours. Mass: 491.26 (M+H).

후처리

  1. customThis compound was synthesized

출처 및 근거

ORD 기록
ord-219088c632a44b0abc9cbbd6a4ec83d5
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285558B2

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