HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-formyl-1-methyl-1H-pyrrole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl 5-formyl-1-methyl-1H-pyrrole-3-carboxylate | HCID 14173855 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-formyl-1-methyl-1H-pyrrole-3-carboxylic acid | HCID 45083779 | 87.3% |
Reaction Steps
methyl 5-formyl-1-methyl-1H-pyrrole-3-carboxylate (0.5 g) dissolved in methanol (5 ml) was treated with 10% aqueous sodium hydroxide (5 ml) at 50° C. for 2 hours. Reaction cooled, acidified with 10% aqueous hydrochloric acid, and extracted with ethyl acetate. Ethyl acetate layer dried, and concentrated to give pure desired acid (0.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07285558B2 |
| Source dataset | uspto-grants-2007_10 |
| ORD ID | ord-21876a9b8e474860a91f79a34db556f2 |
| Source note | uspto-grants-2007_10 |