2-Chloro-N,N-dimethylethylamine → HCID 58981183, compound

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-N,N-dimethylethylamine	HCID 7901	—
Reactant	Triethylamine	HCID 8471	—
Reactant	1,8-Diazabicyclo(5.4.0)undec-7-ene	HCID 81184	—
Reactant	5-methyl-2-(1-naphthylmethyl)-3-(4-pyridinyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione	HCID 136334113	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 58981183	HCID 58981183	158.2%

Reaction Conditions

Temperature	90 °C

Reaction Steps

N-(2-Chloroethyl)-N,N-dimethylamine hydrichloride (0.058 g), followed by triethylamine (0.092 mL) and DBU (0.103 mL), were added to a solution of 5-methyl-2-(1-naphthylmethyl)-3-(4-pyridinyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (0.064 g) in 3:1 dimethylformamide and DMSO (1 mL). The mixture was heated at 90° C. for 18 h then cooled to room temperature. Crude reaction was purified on preparative HPLC to give the title compound (0.120 g). Mass 455.03 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07285558B2
Source dataset	uspto-grants-2007_10
ORD ID	ord-4bb78ebc9e764b0db249188a47de1cc5
Source note	uspto-grants-2007_10