Dimethylformamide → HCID 58980909, compound

Participants

Reaction Steps

Step A) Preparation of N-[tert-butyl(dimethyl)silyl]-1-methyl-1H-imidazole-4-sulfonamide: A mixture of 2.2 g (14 mmol) 1-methyl-1H-imidazole-4-sulfonamide, 2.1 g (14 mmol) t-butyldimethylsilyl chloride and 3.9 mL (28 mmol) triethylamine in 15 mL DMF was stirred at room temperature overnight Solvent was removed, and the residue was dissolved in EtOAc before being washed with water and brine. Drying (MgSO4) and removal of solvent gave 3 g of the subtitle product as a white solid, 1H NMR (DMSO) δ 7.7 (s, 1H), 7.6 (s, 1H), 7.35 (s, 1H), 3.7 (s, 3H), 0.9 (s, 9H)., 0.2 (s, 6H).

Provenance & Evidence