1-Naphthaldehyde → 1-Naphthaldehyde (1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)hydrazone

関与物質

反応手順

A solution of 84 mg (0.54 mmol) 6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione and 84 mg (0.54 mmol) 1-naphthaldehyde in 3 mL DMF was heated to 70° C. for 30 min before cooling to room temperature affording a solution of 1-naphthaldehyde (1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)hydrazone. Isonicotinaldehyde (110 mg, 1.0 mmol) and piperidine (50 μL, 0.6 mmol) were added, and the mixture was heated at 70° C. for 20 h. 1,1,1-trifluoro-2-iodoethane (130 μL, 1.3 mmol) and DBU (200 μL, 1.3 mmol) were added, and the mixture was heated at 90° C. for 20 h. Solvent was removed and the residue was purified by preparative reverse phase HPLC (30%-60% gradient of CH3CN-water with 0.1% TFA) to afford the title compound as the trifluoroacetate salt.

情報源と証拠