Methyl iodide → HCID 58981040, compound

Participants

Reaction Steps

NaH (10 mg, 0.25 mmol) was added to a solution of the compound of Example 164 (84 mg, 0.14 mmol) and CH3I (100 μL) in 2 mL DMF. After warming to room temperature and stirring for 16 h, solvent was removed and the residue was partitioned between water and EtOAc. The EtOAc was separated and washed with brine. Drying and removal of solvent gave an oil that was purified by preparative reverse phase HPLC (45%-75% gradient of CH3CN-water with 0.1% TFA).

Provenance & Evidence