6-Chloroquinoline-4-carbaldehyde → HCID 69430744, compound

Participants

Reaction Steps

A solution of 49 mg (0.23 mmol) 1-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione and 44 mg (0.23 mmol) 6-chloroquinoline-4-carbaldehyde in 1 mL DMF was stirred at room temperature for 5 h to form 6-chloroquinoline-4-carbaldehyde[3-(cyclopropylmethyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]hydrazone. Added was 38 mg (0.34 mmol) 1-methyl-1H-imidazole-5-carbaldehyde and 20 μL piperidine. The mixture was heated at 110° C. for 12 via microwave irradiation. Purification was achieved by preparative HPLC (20%-40% gradient of CH3CN-water with 0.1% TFA) to give the title compound as the bis-TFA salt.

Provenance & Evidence