O-Methylhydroxylamine hydrochloride → HCID 58980992, compound

Participants

Reaction Steps

This compound was made following the procedure described above, starting with 6-hydrazino-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first 5-chloro-1H-indole-3-carbaldehyde, followed by 4-acetyl-1-methyl-1H-pyrrole-2-carbaldehyde. To the isolated 3-(4-acetyl-1-methyl-1H-pyrrol-2-yl)-2-[(5-chloro-1H-indol-3-yl)methyl]-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione was added 4 equivalents of methoxyamine hydrochloride, triethylamie and heated at 80° C. in N,N′dimethylacetamide for 4 h. The mixture was stirred at room temperature for 4 h. The crude reaction product was purified by semi-prep RPHPLC eluting with water/acetonitrile/trfluoroacetic acid mixtures. 536.2 (M+H).

Provenance & Evidence