5-chloro-1H-indole-3-carbaldehyde → HCID 58981123, compound

HRID 1181820Notes

Reaction equation

HRID 1181820 reaction equation
[NH:1]([C:3]1[N:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7](=[O:13])[N:6]([CH3:14])[C:5](=[O:15])[CH:4]=1)[NH2:2].[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][CH:21]=[C:20]2[CH:26]=O.[C:28]([C:31]1[N:32]=[C:33]([CH:37]=O)[N:34]([CH3:36])[CH:35]=1)(=[O:30])[CH3:29]>>[C:28]([C:31]1[N:32]=[C:33]([C:37]2[N:2]([CH2:26][C:20]3[C:19]4[C:23](=[CH:24][CH:25]=[C:17]([Cl:16])[CH:18]=4)[NH:22][CH:21]=3)[N:1]=[C:3]3[C:4]=2[C:5](=[O:15])[N:6]([CH3:14])[C:7](=[O:13])[N:8]3[CH2:9][CH:10]([CH3:11])[CH3:12])[N:34]([CH3:36])[CH:35]=1)(=[O:30])[CH3:29]

Participants

4

Reactant 3

HCID 27953745-chloro-1H-indole-3-carbaldehydeHCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedioneHCID 45083746HCID 45083746, compound

Product 1

HCID 58981123HCID 58981123, compound

Procedure

This compound was made following the procedure described above, starting 6-hydrazino-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione, and condensing first 5-chloro-1H-indole-3-carbaldehyde, followed by 4-acetyl-1-methyl-1H-imidazole-2-carbaldehyde. 508 (M+H).

Sources & evidence

ORD record
ord-be31166c24a24d50b3d3f394519cbb67
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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