反应详情

After dissolving 7-(2,4-dichlorophenyl)-2-ethylpyrazolo[1,5-a]pyridine (280 mg) in acetonitrile (20 mL), nitronium tetrafluoroborate (255 mg) was added 4 times at 30 minute intervals while stirring on ice. The reaction mixture was added to ice water, extraction was performed with ethyl acetate and the extract was washed with water and brine. After drying over anhydrous magnesium sulfate and filtration, the solvent was concentrated under reduced pressure, the residue was purified by silica gel column chromatography, and the title compound (115 mg) was obtained from the n-hexane:ethyl acetate (20:1) fraction as yellow crystals.

1. additionwas added 4 times at 30 minute intervals
2. washthe extract was washed with water and brine
3. dry with materialAfter drying over anhydrous magnesium sulfate and filtration
4. concentrationthe solvent was concentrated under reduced pressure
5. customthe residue was purified by silica gel column chromatography