3-Hexanol → 3-Hexyl 5-amino-4-oxopentanoate Hydrochloride

HRID 1181997Notes

Reaction equation

HRID 1181997 reaction equation
[CH3:1][CH2:2][CH:3]([OH:7])[CH2:4][CH2:5][CH3:6].[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14](O)=[O:15]>>[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14]([O:7][CH:3]([CH2:4][CH2:5][CH3:6])[CH2:2][CH3:1])=[O:15]

Participants

3

Reactant 2

HCID 121783-HexanolHCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 858073313-Hexyl 5-amino-4-oxopentanoate Hydrochloride

Procedure

From 3-hexanol (6.0 ml) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol) at 100° C. The reaction was complete after 2 days. The yield was 0.87 g (58%) of amber oil.

Workup

  1. customat 100° C

Sources & evidence

ORD record
ord-f56ea96cbcf64cd4a0e22a48eddb22a4
Source dataset
uspto-grants-2007_10
Patent number
US07287646B2

Reaction notes

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