4-Fluorobenzylic alcohol → HCID 22253136, compound

HRID 1182003Notes

Reaction equation

HRID 1182003 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1.[ClH:10].[NH2:11][CH2:12][C:13](=[O:19])[CH2:14][CH2:15][C:16](O)=[O:17]>>[ClH:10].[NH2:11][CH2:12][C:13](=[O:19])[CH2:14][CH2:15][C:16]([O:7][CH2:6][C:5]1[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=1)=[O:17]

Participants

3

Reactant 2

HCID 680224-Fluorobenzylic alcoholHCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 22253136HCID 22253136, compound

Procedure

From 4-fluorobenzyl alcohol (5.0 g; 40 mmol) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol). The reaction was complete after 3 h at 90° C. The yield was 1.02 g (62%).

Sources & evidence

ORD record
ord-2f32b0949ffc4bb8a6e8c9cbbfba44c7
Source dataset
uspto-grants-2007_10
Patent number
US07287646B2

Reaction notes

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